Investigations have clarified this problem and point out that stable solutions of phenytoin sodium can be prepared which are safe for intravenous infusion provided the injection is diluted in small volumes of 0
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Details of the Supplier of the Safety Data Sheet Pfizer Inc Pfizer Pharmaceuticals Group
Intramuscular
Fosphenytoin can be administered intramuscularly (IM) or intravenously (IV) but requires enzymatic conversion by phosphatase in the body to the active phenytoin compound
Alternatively, generally accepted guidelines suggest 15 to 20 mg/kg by
Collect spill with Phenytoin is metabolized by the cytochrome P450 enzymes CYP2C9 and CYP2C19
20 mg/kg IV/IO - dilute to a concentration of 10 mg/mL or less and infuse based on body weight: For patients < 75 kg: administer over a minimum of 30 minutes
Lactate injection and administered freshly prepared
For the PO route the adult dose range for the loading dose is also 15-20 mg/kg given in 3 divided doses every 2-4 hours
Fosphenytoin – Fosphenytoin is the generally preferred formulation of phenytoin for rapid intravenous dosing
Background Manufacturers of phenytoin injection recommend that it be given without dilution by direct IV injection
Maintenance dose of phenytoin
CEREBYX® (fosphenytoin sodium injection) is a prodrug intended for parenteral administration; its active metabolite is phenytoin
Careful cardiac monitoring is needed during and after administering
Collect spill with absorbent material
After initial maintenance dose, subsequent doses should be individualized to achieve
Health care workers who handle hazardous drugs are at risk of skin rashes, cancer, and reproductive disorders
17 years Loading dose: 10-15 mg PE/kg IV; 1-2 PE/kg/min, or 150 mg PE/min, whichever is slower; Maintenance dose
List the facility and monitoring elements for compliance with USP <800>
treatment of ventricular tachycardia and paroxysmal tachycardia especially secondary to digoxin toxicity
small red or purple spots on skin
For this reason, serum phenytoin concentrations may increase modestly when IM or IV CEREBYX is substituted for oral phenytoin sodium therapy
Personal Protective Equipment: Refer to applicable national standards and regulations in the selection and use of personal protective equipment (PPE)